Induction of the SOS gene (umuC) by 4-quinolone antibacterial drugs
نویسندگان
چکیده
منابع مشابه
Quinolone Resistance Reversion by Targeting the SOS Response
Suppression of the SOS response has been postulated as a therapeutic strategy for potentiating antimicrobial agents. We aimed to evaluate the impact of its suppression on reversing resistance using a model of isogenic strains of Escherichia coli representing multiple levels of quinolone resistance. E. coli mutants exhibiting a spectrum of SOS activity were constructed from isogenic strains carr...
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DNA damage-inducible mutagenesis in Escherichia coli is largely dependent upon the activity of the UmuD (UmuD') and UmuC proteins. The intracellular level of these proteins is tightly regulated at both the transcriptional and the posttranslational levels. Such regulation presumably allows cells to deal with DNA damage via error-free repair pathways before being committed to error-prone pathways...
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ژورنال
عنوان ژورنال: Journal of Medical Microbiology
سال: 1992
ISSN: 0022-2615,1473-5644
DOI: 10.1099/00222615-36-2-78